0
ÔÝÎÞ
±¾ÕÂÕûÌåÊǹØÓÚδÀ´°¢¶û´Äº£Ä¬²¡ºÍÆäËûÈÏÖªÕÏ°Ö¢ÖÎÁƺͻ¤ÀíµÄһЩÌÖÂÛ£¬°üÀ¨Ò©ÎïÖÎÁÆ¡¢·ÇÒ©ÎïÖÎÁÆ¡¢Õþ²ß·ö³Ö£¬ÒÔ¼°ÈçºÎÓªÔìÒ»¸öÈÏÖªÓÑÉƵÄÉçȺ¡£ ÔÚ±¾×¨À¸½«ÒªÍê¸å֮ʱ£¬Ç¡·êÂ̹ȵİ¢¶û´Äº£Ä¬²¡ÐÂÒ©Íê³ÉÁÙ´²ÈýÆÚÊÔÑé¡£11 Ô 2 ÈÕ£¬¹ú¼ÒÒ©¼à¾Ö¹ÙÍø·¢²¼¹«¸æ£¬ÓÐÌõ¼þÅú×¼Çá¶ÈÖÁÖжȰ¢¶û´Äº£Ä¬²¡Ò©Îï¸Ê¶ÌØÄƽºÄÒ£¨GV-971£©ÉÏÊС£´ËÇ°ÉÔÔçʱ¼ä£¬10 Ô 22 ÈÕ£¬ÃÀ¹ú Biogen ¹«Ë¾ºÍÆäÈÕ±¾ºÏ×÷»ï°é Eisai Ðû²¼½«Ïò FDA ÉêÇëÕë¶ÔÔçÆÚ°¢¶û´Äº£Ä¬²¡ÖÎÁÆÒ©Îï Aducanumab µÄÉúÎïÖÆÆ·Ðí¿ÉÉÏÊÐÉêÇë¡£ ÔÚҽҩѧ·½Ã棬ÎÒÊǸöÈ«È»µÄÃÅÍ⺺£¬Ö»ÊǸøѧÉúÉÏ¿Î˵ÈÏÖªÕÏ°Ö¢·ÇÒ½Ò©Àà½éÈë·½·¨Ö®Ç°Òª½²Ò©ÎïÊÇÓÐÓõġ¢²»Í¬½×¶ÎÐèÒª²»Í¬µÄÒ©ÎÒÔ¼°×Ô 2003 ÄêÒÔÀ´ÔÙҲûÓÐÒ©Îï»ñµÃÃÀ¹úʳƷҩƷ¼à¶½¹ÜÀí¾Ö£¨FDA£©µÄÅú×¼£¬Ñз¢°¢¶û´Äº£Ä¬²¡µÄÒ©ÎïÊÇÐí¶àÒ©³§µÄ¡¸·ØĹ¡¹£¬´óÁ¿µÄ×ÊԴͶÈëȴûÓнá¹û¡£´ó¼ÒÌáµ½ Biogen ºÍ Eisai ÐÂÒ©µÄʱºòÒ²×Ü»á´øÉϺóÃæµÄ¡¸Î²°Í¡¹£¬Biogen ¹«Ë¾Òò´ËÏûÏ¢¹ÉƱ¼¤Ôö 30%£¬ÕâºóÃæ¿Ï¶¨ÊÇÓÐÀûÒæÇý¶¯µÄ¡£ËùÒÔÂ̹ÈÄÜÓÐÐÂÒ©½øÈ빫ÖÚÊÓÒ°»¹ÊÇͦÁîÈËÕñ·ÜµÄ£¬¶øÇÒÆäËùÕë¶ÔµÄ²¡ÀíºÍ֮ǰµÄÒ©ÎïÑз¢Â·×Ó²»Í¬£¬Ö÷ÒªÕë¶ÔµÄÊdz¦µÀ¾úȺÎÉÂÒËùÓÕ·¢µÄÉñ¾Ñ×Ö¢¡£ ¹ØÓÚ GV-971 ºÍ Aducanumab£¬ÓÐÐËȤµÄÅóÓѲ»·Á×Ô¼ºÈ¥ËÑË÷Ïà¹Ø×ÊÁÏÔĶÁ£¬ÕâÒ²ÊÇÒ»¸ö×ÔÎÒѧϰµÄÆõ»ú£¬¶ÔÎÒÀ´ËµÒ²ÊÇ¡£ÔÚÀÏÄêÈËÓÃÒ©ÉÏ£¬ÎÒÓиö×Ô¼ºÁýͳµÄ¸ÅÄ¾ÍÊǸöÌå²îÒì»á±ÈȺÌå²îÒìÀ´µÃ´ó¡£Ê²Ã´Òâ˼ÄØ£¿±ÈÈç˵Èý¸ö¶¼»¼ÓÐÈÏÖªÕÏ°Ö¢µÄÀÏÈË£ºµÚÒ»¸öÉíÌå´óÖ½¡¿µ£¬Ã»Óг¤ÆÚ·þÓÃÆäËûÒ©ÎÁíÒ»¸öÊÇÈý¸ß£¬Ã¿ÌìÒ»°ÑҩƬ£»×îºóÒ»¸öÔø¾Õï¶ÏΪÁÙ´²ÒÖÓôÖ¢£¬·þÓùý¿¹ÒÖÓôµÄÒ©Î×î½üÒ»Ä긴·¢£¬ÏÖÔÚÈÔÔÚ·þҩά³Ö¡£ÄÇͬһ¿î°¢¶û´Äº£Ä¬²¡µÄÒ©Î¶ÔÕâÈý¸öÈË»áÓв»Í¬Ð§¹ûÂð£¿ÀÏÈ˶ಡÆë·¢µÄʱºò»áÔÚÓÃÒ©É϶àºÜ¶à¿¼Á¿£¬ÓÐЩ¾Ã²¡³ÉÒ½µÄÖªµÀ×Ô¼º»á¶ÔijЩ³É·Ö¹ýÃô¡¢¿¹Ò©£¬»òÕßÓÐÆäËû²»Á¼·´Ó¦£¬ËùÒÔÐèÒªÌáÐÑ»¼ÕßÁôÒâ×Ô¼ºµÄÉíÌå·´Ó¦£¬¼°Ê±ºÍÒ½Éú·´À¡£¬µ÷Õû¼ÁÁ¿ÉõÖÁ¸ü»»Ò©Æ·¡£ Ç°ÎÄÌáµ½µÄÒôÀÖÖÎÁƾÍÊÇ·ÇÒ©ÎïÖÎÁƵÄÒ»ÖÖ£¬³ý´ËÖ®ÍâÓÐʵ֤µÄÖÎÁÆ·½Ê½»¹°üÀ¨Ã廳ÖÎÁÆ¡¢ÈÏ֪ѵÁ·¡¢ÈÏÖª¿µ¸´¡¢ÈÏÖª´Ì¼¤µÈµÈ¡£ÕâÀïÏë¸ú´ó¼ÒÖصã½éÉÜÒ»ÏÂÈÏÖª´Ì¼¤ÁÆ·¨(Cognitive Stimulation Therapy, CST)£¬Ò»À´ËüÊÇÓ¢¹ú¹ú¼Ò½¡¿µÓëÕÕ¹Ë׿ԽÑо¿Ôº£¨National Institute for Health and Care Excellence£¬NICE£©Î¨Ò»Ð´ÈëÈÏÖªÕÏ°Ö¢»¼ÕßÖÎÁÆÖ¸ÄϵķÇÒ©Îï·½°¸£¬Òâ˼¾ÍÊÇ£¬È¥Ò½ÔºÄõ½Õï¶ÏÊéÖ®ºóÒ½Éú»á¸æËßÄãÈ¥ÄĶù½ÓÊÜ CST ÖÎÁÆ£»¶þÀ´ CST ÒѾÓÐÁËÖÐÎĵİ汾£¬ÖйúÏã¸ÛÓÉÎÒËùÔڵIJ¿ÃÅ×öÁ˱¾ÍÁ»¯£¬²¢¾¹ýʵ֤£¬±±¾©´óѧҽÁƲ¿Ò²ÓÐÀÏʦ×öÁËÆÕͨ»°°æ±¾µÄ±¾ÍÁ»¯¡£ÖµµÃÒ»ÌáµÄÊÇ£¬²»Òª±»¡¸´Ì¼¤¡¹Á½¸ö×ÖÎóµ¼ÁË£¬Ëü²»ÊÇÖ¸µç»÷¡¢µçÁÆ£¬¸úµçûÓÐÈκεĹØϵ£»¶øÊÇͨ¹ýÈÕ³£Éú»îÖеĻ»î»¯»¼ÕߵĴóÄÔ¡£±±´óÍŶӣ¨»ÆÔÃÇÚ½ÌÊÚ¡¢ÁõÕØÈðÀÏʦ£©Ö®ºó½«Æä·Òë³ÉÁË¡¸ÈÏÖª´Ù½øÖÎÁÆ¡¹¡£ÈÕ±¾µÄ·ÒëÒ²²»´í£¬¿´ºº×ֵĻ°ÊÇ¡¸ÈÏÖª»î»¯ÁÆ·¨¡¹¡£ CST ΪÖжÈÖÁÇá¶ÈÈÏÖªÕÏ°Ö¢»¼ÕßÌṩµÄ·ÇÒ©ÎïÖÎÁÆ£¬×î³õÉè¼ÆµÄʱºòÒÔС×éµÄÐÎʽչ¿ª£¬Ò»¹² 14 ½Ú£¬Ã¿ÖÜ 2 ½Ú¡£14 ½ÚÄÚÈÝ°üÀ¨£º (µÚ 1 ½Ú) ÌåÄܻ£»(µÚ 2 ½Ú) ÉùÒô£»(µÚ 3 ½Ú)ͯÄêÍùÊ£»(µÚ 4 ½Ú)ʳÎ(µÚ 5 ½Ú)ʱÊ£»(µÚ 6 ½Ú)Ãæ¿×/¾°Î(µÚ 7 ½Ú)ÎÄ×ÖÁªÏ룻(µÚ 8 ½Ú)´´Ò⣻(µÚ 9 ½Ú)Îï¼þ·ÖÀࣻ(µÚ 10 ½Ú)µ¼Ïò£»(µÚ 11 ½Ú)½ðÇ®ÔËÓã»(µÚ 12 ½Ú)Êý×ÖÓÎÏ·£»(µÚ 13 ½Ú)ÎÄ×ÖÓÎÏ·£»(µÚ 14 ½Ú)С×é±ÈÈü¡£ ´ó¼Ò¿´µ½ÄÚÈÝ¿ÉÄÜ»á¾õµÃºÜÈÕ³£»¯£¬ÕâÕýÊÇ CST µÄ¾«Ë裬ͨ¹ýÏÖʵÉú»îÖеij¡¾°»î»¯»¼ÕߵĴóÄÔ¡£ÒÔǰʵÑéÊÒÀïÃæµÄÈÏ֪ѵÁ·£¬ÑµÁ·ËãÊý¡¢¼ÇÒäͼÐÎÊý×Ö£¬·Åµ½ÏÖʵÉú»îÖÐûʲôÒâÒ壬ÎÒÃÇÔÚÏÖʵÉú»îÖÐ×öµ½µÄÊÂÇéÍùÍùÊǼ¯ºÏÁ˶àÖÖÄÜÁ¦µÄ£¬±ÈÈç¼Æ»®¡¢¼ÇÒä¡¢Ö´ÐС£¾ÙÒ»¸ö CST µÄÀý×Ó£¬µÚ 11 ½Ú½ðÇ®ÔËÓ㬱¾½Ú¿ªÕ¹µÄ·½Ê½¿ÉÒÔÊÇÔÚÖÐÐÄ°Ú·ÅһЩʳ²Ä£¬ÉÏÃæ±êÃ÷¼Û¸ñ£¬È»ºó¸ø»¼Õß 100 ¿éÇ®£¬ÈÃËûÑ¡Ôñ¹ºÂò¿ÉÒÔ¸øÈý¸öÈË×öÍí·¹µÄʳ²Ä¡£ÒªÍê³ÉÕâ¸öÈÎÎñ£¬»¼ÕßÐèÒª¼Æ»®Íí·¹Ò»°ã³Ôʲô£¬Èý¸öÈËÐèÒª¶àÉÙʳÎTA ÊÖÀïµÄÇ®¿ÉÒÔÔõôÀûÓ᣻¼ÕßÔÚ¹ý³ÌÖÐÒ²Ðí»¹»áºÍÉ繤¹µÍ¨£¬ËµÕâ·¹ÊǸøË×öµÄ£¬TA °®³Ôʲô£¬µÈµÈ¡£ÔÚÕâ¹ý³ÌÖл¼Õ߻᷸´í£¬Ð¡×é´øÁìÔ±µÄ¹¤×÷ÊÇÔÚΪ»¼Õß³äȨ(Empower)µÄͬʱ£¬¸ø TA Êʵ±µÄÖ¸Òý¡¢¹ÄÀø£¬Èà TA ¾õµÃ×Ô¼ºÄÜ×öµ½£»²¢ÇÒ»¹ÒªÊ±¿ÌÁôÒâС×é³ÉÔ±Ö®¼ä½»Á÷ÖпÉÄܳöÏÖµÄÎÊÌ⣬ÀýÈç¹ý¼¤µÄÆÀÂÛ¡¢²»¹µÍ¨µÈµÈ£»ËùÒÔ´øÁìÒ»¸ö CST С×éÊǺܿ¼Ñé´øÁìÔ±¹¦Á¦µÄ¡£ Ó¢¹ú UCL µÄ CST ¹¤×÷×黹ÍƳöÁ˸ø¼ÒÍ¥ÕÕ¹ËÕßʹÓÃµÄ CST Êֲᣬ×î½ü»¹ÍƳöÁ˵çÊӰ棬ÑûÇëÁËÒѾÊÜѵµÄרҵÈËÊ¿ºÍÈÏÖªÕÏ°Ö¢»¼ÕßÒ»Æð£¬ÅÄÉã¼Ç¼ÏÂËûÃǵĻ¥¶¯£¬Èû¼ÕßÔÚ¼ÒÀï´ò¿ªµçÊÓÒ²ÄܽÓÊÜÈôóÄÔ»îÔ¾ÆðÀ´µÄѶϢ¡£CST µÄÖÐÎİ棨¹ã¶«»°¡¢ÆÕͨ»°£©¶¼ÔÝʱ»¹Ã»Óиø¼ÒÍ¥ÕÕ¹ËÕߵİ汾ÍƳö£¬µ«Ð¡×é°æ±¾µÄÊÖ²á¼ÒÈËÒ²¿ÉÒԲο¼¡£´ó¼ÒÈç¹ûÓÐÐËȤµÄ»°¿ÉÒÔÉÏÍøÑ°ÕÒ×ÊÔ´ºÍ¶©¹º¡£
¡¸Ã»ÓÐÕ½ÂԼƻ®µÄÕþ²ßÖ»ÊÇ¿ÕÏ룻¶øûÓÐÕþ²ßÖ¸ÒýµÄ¼Æ»®Ö»ÊǺÁÎÞÄ¿µÄ¡¢ÔÓÂÒÎÞÕµĻÇåµ¥¡£¡¹
¹²ÌõÆÀÂÛ ÎÒÒª·¢±íÆÀÂÛ
Á¬ÔØÖÐ
¡¾³èˬÎÄ¡¿¡°ÀÏÆÅ¡¡¡±¡°ËÊÇÄãÀÏÆÅ£¿¡±Àë»é3Äêºó£¬ÓÖÀÏÔĶÁ
¡°Ò¯£¬·òÈËÉÏÁ˳¼Ïà·òÈ˵ÄÂí³µ¡£¡± ¡°¶÷¡£¡±Ä³Äв»ÉõÔĶÁ